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Venetoclax + chemo disappoints in double-hit lymphoma trial

Venetoclax + chemo disappoints in double-hit lymphoma trial

27 Dec 2021 byAudrey Abella

In patients with double-hit lymphoma (DHL), the addition of the BCL2 inhibitor venetoclax to a chemoimmunotherapeutic regimen comprising DA-EPOCH-R* led to excess treatment-related mortality compared with DA-EPOCH-R alone, according to the initial results of the phase II/III Alliance A051701 trial.

Venetoclax + chemo disappoints in double-hit lymphoma trial

27 Dec 2021
Asian-derived polygenic risk scores boost risk stratification for breast cancer

Asian-derived polygenic risk scores boost risk stratification for breast cancer

27 Dec 2021 byTristan Manalac

Drawing from the largest available studies of Asian breast cancer patients, a recent Singapore study has developed polygenic risk scores (PRS) that can help improve the risk stratification of women of Asian ancestry.

Asian-derived polygenic risk scores boost risk stratification for breast cancer

27 Dec 2021
Lumateperone improves depression symptoms in bipolar disorder

Lumateperone improves depression symptoms in bipolar disorder

26 Dec 2021

Treatment with 42-mg lumateperone daily leads to significant improvement in depression symptoms, with no serious safety issues, among patients with major depressive episodes associated with both bipolar I and II disorders, a study has shown.

Lumateperone improves depression symptoms in bipolar disorder

26 Dec 2021