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How effective is adjunctive dexmedetomidine for alcohol withdrawal in ICU patients?

15 Jun 2022

In critically ill patients with alcohol withdrawal syndrome (AWS), adding dexmedetomidine to symptom-triggered benzodiazepines appears to cause no significant change in Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scores from baseline compared to symptom-triggered therapy alone, a recent study has found.

How effective is adjunctive dexmedetomidine for alcohol withdrawal in ICU patients?

15 Jun 2022

Sweetened drinks, sugar intake up incidence, mortality of proximal colon cancer

15 Jun 2022 by

Consumption of sugar and sugar-sweetened beverages (SSBs) appears to increase proximal colon cancer incidence and mortality, particularly during later stage of tumorigenesis, reports a study.

Sweetened drinks, sugar intake up incidence, mortality of proximal colon cancer

15 Jun 2022

Familiarity with EuroLupus dosing for cSLE remains low despite uptick in use

15 Jun 2022

Paediatric specialists now use low-dose EuroLupus cyclophosphamide (CYC) more than they did a decade ago in the treatment of childhood-onset systemic lupus erythematosus (cSLE), reports a study in North America. However, familiarity with EuroLupus dosing is still low.

Familiarity with EuroLupus dosing for cSLE remains low despite uptick in use

15 Jun 2022

Sarilumab shows potential for relapsing polymyalgia rheumatica

15 Jun 2022 by

The monoclonal antibody sarilumab demonstrated significant efficacy in individuals with relapsing polymyalgia rheumatica (PMR), findings from the phase III SAPHYR trial have shown.

Sarilumab shows potential for relapsing polymyalgia rheumatica

15 Jun 2022

Diet-induced remission tied to metabolome changes in kids with Crohn’s disease

15 Jun 2022 by

Crohn’s disease (CD) remission, induced by either CD exclusion diet with partial enteral nutrition (CDED+PEN) or by exclusive enteral nutrition (EEN), leads to significant changes in metabolite levels in paediatric patients, according to a new study.

Diet-induced remission tied to metabolome changes in kids with Crohn’s disease

15 Jun 2022

$Trifluridine/tipiracil polypill shows modest clinical activity against refractory ESCC$

Trifluridine/tipiracil polypill shows modest clinical activity against refractory ESCC

15 Jun 2022

The fixed-dose combination of trifluridine/tipiracil may be feasible for use in the treatment of patients with refractory esophageal squamous cell carcinoma (ESCC), with the drug showing modest clinical activity in the phase II ECTAS study.

Trifluridine/tipiracil polypill shows modest clinical activity against refractory ESCC

15 Jun 2022

Abundant sialylated oligosaccharides in breastmilk may impair infant nutrition

15 Jun 2022

Elevated levels of sialylated human milk oligosaccharides (HMO) in mothers’ breastmilk appears to worsen infant nutritional status, reports a Bangladesh study.

Abundant sialylated oligosaccharides in breastmilk may impair infant nutrition

15 Jun 2022

Rheumatoid arthritis linked to increased risk of out-of-hospital cardiac arrest among women

15 Jun 2022

Out-of-hospital cardiac arrest (OHCA) tend to occur at a higher rate among patients with rheumatoid arthritis (RA), and this risk increase is especially pronounced in women but not observed in men, a study has found.

Rheumatoid arthritis linked to increased risk of out-of-hospital cardiac arrest among women

15 Jun 2022

Original New Drug Application Approvals by US FDA (01 - 15 June 2022)

15 Jun 2022

New drug applications approved by US FDA as of 01 - 15 June 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (01 - 15 June 2022)

15 Jun 2022

Venetoclax boosts HRQoL in AML patients unfit for intensive chemotherapy

14 Jun 2022

Drug combinations including venetoclax seem to have a positive impact on health-related quality of life (HRQoL), or at least does not worsen it, in patients with acute myeloid leukaemia (AML) who are ineligible for intensive chemotherapy, a recent study has found.

Venetoclax boosts HRQoL in AML patients unfit for intensive chemotherapy

14 Jun 2022

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How effective is adjunctive dexmedetomidine for alcohol withdrawal in ICU patients?

How effective is adjunctive dexmedetomidine for alcohol withdrawal in ICU patients?

Sweetened drinks, sugar intake up incidence, mortality of proximal colon cancer

Sweetened drinks, sugar intake up incidence, mortality of proximal colon cancer

Familiarity with EuroLupus dosing for cSLE remains low despite uptick in use

Familiarity with EuroLupus dosing for cSLE remains low despite uptick in use

Sarilumab shows potential for relapsing polymyalgia rheumatica

Sarilumab shows potential for relapsing polymyalgia rheumatica

Diet-induced remission tied to metabolome changes in kids with Crohn’s disease

Diet-induced remission tied to metabolome changes in kids with Crohn’s disease

Trifluridine/tipiracil polypill shows modest clinical activity against refractory ESCC

Trifluridine/tipiracil polypill shows modest clinical activity against refractory ESCC

Abundant sialylated oligosaccharides in breastmilk may impair infant nutrition

Abundant sialylated oligosaccharides in breastmilk may impair infant nutrition

Rheumatoid arthritis linked to increased risk of out-of-hospital cardiac arrest among women

Rheumatoid arthritis linked to increased risk of out-of-hospital cardiac arrest among women

Original New Drug Application Approvals by US FDA (01 - 15 June 2022)

Original New Drug Application Approvals by US FDA (01 - 15 June 2022)

Venetoclax boosts HRQoL in AML patients unfit for intensive chemotherapy

Venetoclax boosts HRQoL in AML patients unfit for intensive chemotherapy