Hypersensitivity to amlodipine, valsartan, HCTZ or other sulfonamide derivatives. Concomitant use w/ aliskiren-containing products in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m
2). Pregnancy. HCTZ: Biliary cirrhosis, cholestasis, anuria, patients undergoing dialysis, refractory hypokalaemia, hyponatraemia, hypercalcaemia & symptomatic hyperuricaemia. Severe hepatic & renal (CrCl <30 mL/min) impairment.