GP-Allopurinol Dosage & Drug Information

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Core Prescribing Info

Contents

Allopurinol

Indications/Uses

Reduction of urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (eg, gouty arthritis, skin tophi, nephrolithiasis) or predictable clinical risk (eg, malignancy potentially leading to acute uric acid nephropathy). Management of 2,8-dihydroxyadenine renal stones related to deficient activity of adenine phosphoribosyltransferase; recurrent mixed calcium oxalate renal stones in the presence of hyperuricosuria, when fluid, dietary & similar measures have failed.

Dosage/Direction for Use

Adult Initially 100 mg daily, may increased only if w/ unsatisfactory serum urate response. Alternatively, 2-10 mg/kg daily. Mild conditions 100-200 mg daily. Moderately severely conditions 300-600 mg daily. Severe conditions 700-900 mg daily. Childn <15 yr 10-20 mg/kg daily. Max: 400 mg daily. Elderly Lowest dosage which produced satisfactory urate reduction. Severe renal impairment <100 mg daily or single dose of 100 mg at longer intervals than 1 day. Dialysis (2-3x wkly) 300-400 mg after each dialysis session.

Administration

Should be taken with food.

Contraindications

Hypersensitivity.

MIMS Class

Hyperuricemia & Gout Preparations

ATC Classification

M04AA01 - allopurinol ; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.

Presentation/Packing

Form

GP-Allopurinol tab 300 mg

Packing/Price

1's

GP-Allopurinol

allopurinol

Manufacturer:

Indoco