Revolade

Immune thrombocytopenia (ITP) in adult patients who are refractory to other treatments (eg, corticosteroids & Ig). ITP lasting ≥6 mth from diagnosis in paed patients ≥6 yr who are refractory to other treatments (eg, corticosteroids, Ig). Adult patients w/ chronic HCV infection for thrombocytopenia. In combination w/ standard immunosuppressive therapy for 1st-line treatment of adult & adolescent ≥12 yr w/ severe aplastic anemia. Adult patients w/ acquired severe aplastic anemia (SAA) who were either refractory to prior immunosuppressive therapy or heavily pretreated & are unsuitable for haematopoietic stem cell transplantation.

Individualised dosage based on patient's platelet counts. ITP Initially 50 mg once daily. East-/Southeast-Asian patient 25 mg once daily. Adjust dose to achieve & maintain platelet count ≥50,000/microL. Observe patient's response for at least 2 wk prior to another dose adjustment. Standard dose adjustment: 25 mg once daily. Max: 75 mg daily. Hepatic impairment Initially 25 mg once daily, wait 3 wk before dose increase. Chronic HCV-associated thrombocytopenia Adult Initially 25 mg once daily, may be increased by 25 mg increments every 2 wk. Max: 100 mg once daily. Hepatic impairment Initially 25 mg once daily. 1st-line severe SAA Patient ≥12 yr 150 mg once daily for 6 mth. Initiate concurrently w/ standard immunosuppressive therapy. Asian patient ≥12 yr & those w/ mild, moderate or severe hepatic impairment Initially 75 mg once daily for 6 mth. Refractory SAA Adult Initially 50 mg once daily. East-/Southeast-Asian patient Initially 25 mg once daily. Adjust dose in 50 mg increments every 2 wk as necessary to achieve target platelet count ≥50,000/microL. Max: 150 mg daily. Chronic HCV & refractory SAA Hepatic impairment Initially 25 mg once daily.

May be taken with or without food: Take at least 2 hr before or 4 hr after antacids, dairy products or other mineral supplements containing polyvalent cations (eg, Al, Ca, Fe, Mg, Se & Zn). May be taken w/ food containing little (<50 mg) or preferably no Ca.

Hypersensitivity.

Haemostatics

B02BX05 - eltrombopag ; Belongs to the class of other systemic hemostatics. Used in the treatment of hemorrhage.

POM