IV Administer infusion via peripheral line on wk 1 & 2 to minimize infusion-related reaction, & via central line for subsequent wk. Premed: Diphenhydramine 25-50 mg or equiv orally 30-60 min prior to infusion, or as IV 15-30 min prior to infusion. Acetaminophen 650-1,000 mg orally 30-60 min prior to infusion, or as IV 15-30 min prior to infusion. Dexamethasone 20 mg or equiv as IV 60-120 min prior to infusion, & 10 mg or equiv as IV 45-60 min prior to infusion. Administer at initial dose (wk 1, days 1 & 2) & optional for subsequent doses.
Monotherapy in 3-wk dosing schedule Adult (≥18 yr) weighing ≥80 kg 1,750 mg (5 vials), followed by 2,100 mg (6 vials) every 3 wk starting at wk 7 onwards,
<80 kg 1,400 mg (4 vials) followed by 1,750 mg (5 vials) every 3 wk starting at wk 7 onwards. Dosing schedule: Wk 1-4: Wkly (total of 4 doses): Wk 1: Split infusion on days 1 & 2; wk 2-4: Infusion on day 1.
Monotherapy in 2-wk dosing schedule Adult (≥18 yr) weighing ≥80 kg 1,400 mg (4 vials),
<80 kg 1,050 mg (3 vials). Dosing schedule: Wk 1-4: Wkly (total of 4 doses): Wk 1: Split infusion on days 1 & 2; wk 2-4: Infusion on day 1. Wk 5 onwards: Every 2 wk starting at wk 5.
Combination w/ carboplatin & pemetrexed Administer in the following order: Pemetrexed 500 mg/m
2 every 3 wk until disease progression or unacceptable toxicity. Carboplatin AUC 5 every 3 wk for up to 12 wk. Rybrevant every 3 wk (follow 3-wk dosing schedule), continue until disease progression or unacceptable toxicity.
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