Vaborem Dosage & Drug Information

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Core Prescribing Info

Contents

Meropenem trihydrate, vaborbactam

Indications/Uses

Adults w/ complicated UTI (cUTI) including pyelonephritis; complicated intra-abdominal infection (cIAI); hospital-acquired pneumonia (HAP) including ventilator-associated pneumonia (VAP). Patients w/ bacteraemia that occurs in association w/, or is suspected to be associated w/ previously listed infections.

Dosage/Direction for Use

IV Administer via infusion over 3 hr. Patient w/ CrCl ≥40 mL/min cUTI including pyelonephritis & cIAI 2 g/2 g every 8 hr for 5-10 days, may be continued up to 14 days. HAP including VAP 2 g/2 g every 8 hr for 7-14 days. Bacteraemia in association w/, or suspected to be associated w/ previously listed infections 2 g/2 g every 8 hr. Duration of treatment is in accordance w/ the infection site. Renal impairment CrCl 20-39 mL/min 1 g/1 g every 8 hr, 10-19 mL/min 1 g/1 g every 12 hr, <10 mL/min 0.5 g/0.5 g every 12 hr.

Contraindications

Hypersensitivity to meropenem, vaborbactam or any carbapenems. Severe hypersensitivity (eg, anaphylactic & severe skin reactions) to any other type of β-lactam antibacterials (eg, penicillins, cephalosporins or monobactams).

MIMS Class

Other Beta-Lactams

ATC Classification

J01DH52 - meropenem and vaborbactam ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.

Regulatory Classification

POM

Presentation/Packing

Form

Vaborem powd for soln for infusion 1 g/1 g

Packing/Price

1's

Vaborem

Manufacturer:

ACS Dobfar