Hypersensitivity to cetirizine diHCl, pseudoephedrine HCl, ephedrine or any other piperazines (eg, hydroxyzine). Severe or uncontrolled HTN or severe ischaemic heart disease, uncontrolled hyperthyroidism, severe arrhythmias, phaeochromocytoma, elevated IOP, urinary retention, glaucoma; history of stroke & high risk of haemorrhagic stroke. Concomitant administration of dihydroergotamine & treatment w/ MAOIs (w/in 2 wk after discontinuation). Severe renal impairment (GFR <30 mL/min). Childn <12 yr.