Camelon 4/Camelon 8 Dosage/Direction for Use

Camelon 4: The initial dosage of CAMELON 4 Tablets may vary from 4 mg to 48 mg as Methylprednisolone per day depending on the specific disease entity being treated. In situations less severity, lower doses will generally suffice while in selected patients higher initial doses may be required. Clinical situation in which high dose therapy may be indicated include multiple sclerosis (160 mg/day for a week followed by 64 mg every other day for 1 month have been shown to be effective). If after a reasonable period of time there is a lack of satisfactory clinical response, CAMELON 4 should be discontinued and the patient transferred to other appropriate therapy.
If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrement at appropriate time interval until the lowest dosage which will maintain an adequate clinical response is reacted. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situation which may make dosage adjustment necessary are changes in clinical status secondary to remission or exacerbation in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situation not directly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of CAMELON 4 for a period of time consistent with the patient's condition.
It should be emphasized that dosage requirements are variable and must be individualized on the basis of the disease under treatment and the response of the patient.
Alternate Day Therapy (ADT). Alternate day therapy is a corticosteroid dosing regimen in which twice the usual daily dose of corticosteroid is administered every other morning. The purpose of this mode of therapy is to provide a patient requiring long-term pharmacologic dose treatment with the beneficial effect of corticosteroid, including pituitary-adrenal suppression, the Cushingoid state, corticoid withdrawal symptoms, and growth suppression in children.
Elderly patient: Treatment of elderly patients, particularly if long-term, should be planned bearing in mind the more serious consequences of the common side effects of corticosteroid in old age, particularly osteoporosis, diabetes, hypertension, susceptibility to infection and thinning of skin.
Children: In general dosage for children should be based upon clinical response and is at the discretion of the clinician. Treatment should be limited to the minimum dosage for the shortest period of time. If possible, treatment should be administered as a single dose on alternate days.
Camelon 8: Treatment is initiated with comparatively high doses that are reduced in the further course of treatment until a satisfactory result has been reached.
Subsequent to successful initiation of treatment, the daily dose is reduced gradually until the minimum dose required for maintenance.
Treatment for children should be limited to the minimum dosage for the shortest possible time.
Initial doses: Adults: 4-80 mg daily.
Children: 0.8-1.1 mg/kg body weight.
Maintenance doses: Adults : 4-8 mg daily, the dosage may be increased up to 16 mg daily.
Children: 2-4 mg daily, the dosage may be increased up to 8 mg daily.
Substitution doses: 4-8 mg (in Addison's disease, as an adjuvant to mineralocorticoid therapy), in stressful situation, up to 16 mg daily.
In hypothyroid patients or patients with hepatic cirrhosis comparatively low doses may be sufficient and a general dose reduction may be necessary.
Treatment must only be interrupted or stopped on medical advice.
After prolonged treatment, particularly with comparatively high doses, CAMELON must not be discontinued abruptly, but gradually.
The entire daily dose should be taken early in the morning with sufficient amounts of liquid, during or immediately after a meal.
In the event of shock or other peracute situations, glucocorticoids must be administered intravenously.