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Combinations Metformin Hydrochloride and Glibenclamide are contraindicated in patients with: Hypersensitivity to Metformin Hydrochloride or Glibenclamide or other Sulfonylurea(s) and Sulfonamide(s) or to any of the excipients.
Diabetic pre-coma.
Any type of metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels 1.5 mg/dL [males], 1.4 mg/dL [females], or abnormal creatinine clearance) which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia.
Disease which may cause tissue hypoxia (especially acute disease, or worsening of chronic disease) such as decompensated heart failure, respiratory failure, recent myocardial infarction, shock.
Hepatic insufficiency, acute alcohol intoxication, alcoholism.
Porphyria.
Lactation.
In association with Miconazole.
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