Servalin Injection

Aerobic & facultative gm +ve microorganisms: Enterococcus faecium (vancomycin-resistant strains only), Staph aureus (including methicillin-resistant strains), Strep agalactiae, Strep pneumoniae (penicillin-susceptible strains only), Strep pyogenes. Nosocomial pneumonia; community-acquired pneumonia (including concurrent bacteremia); complicated skin & skin structure infections (including diabetic foot infections, w/o concomitant osteomyelitis); uncomplicated skin & skin structure infections; vancomycin-resistant Enterococcus faecium infections (including concurrent bacteremia).

Adult Infection due to MRSA 600 mg every 12 hr. Adult & adolescent ≥12 yr Nosocomial pneumonia, community-acquired pneumonia including concurrent bacteremia, complicated skin & skin structure infection 600 mg every 12 hr for 10-14 days. Vancomycin-resistant Enterococcus faecium infection including concurrent bacteremia 600 mg every 12 hr for 14-28 days. Ped patient (birth through 11 yr) Nosocomial pneumonia, community-acquired pneumonia including concurrent bacteremia, complicated skin & skin structure infection 10 mg/kg every 8 hr for 10-14 days. Vancomycin-resistant Enterococcus faecium infection including concurrent bacteremia 10 mg/kg every 8 hr for 14-28 days. Pre-term neonate <7 days (gestational age <34 wk) Initiate 10 mg/kg every 12 hr, may consider 10 mg/kg every 8 hr in neonate w/ sub-optimal clinical response.

Hypersensitivity. Not to be administered in patients w/ uncontrolled HTN; pheochromocytoma; thyrotoxicosis; bipolar disorder; schizoaffective disorder; acute confusional state; carcinoid syndrome. Not to be used in patients taking monoamine oxidase A or B inhibitors (eg, phenelzine, isocarboxazid, selegiline, moclobemide) or w/in 2 wk of taking any such medicinal product; directly & indirectly acting sympathomimetic agents (eg, pseudoephedrine), vasopressive agents (eg, epinephrine, norepinephrine), dopaminergic agents (eg, dopamine, dobutamine); serotonin re-uptake inhibitors, TCAs, serotonin 5HT₁ receptor agonists (triptans), meperidine, bupropion, or buspirone.

Not indicated for treatment of gm -ve infections. Not to be used for treatment of patients w/ catheter-related bloodstream or catheter-site infections. Monitor CBC wkly in patients receiving treatment, particularly those receiving for >2 wk, w/ increased hemorrhagic risk, w/ pre-existing myelosuppression, receiving concomitant drugs that produce bone marrow suppression or drugs w/ tendency to decrease Hb, platelet count or function, or w/ chronic infection who have received previous or concomitant antibiotic therapy. Discontinue therapy in patients who develop or have worsening myelosuppression; w/ suspected or confirmed C. difficile-associated diarrhea is suspected or confirmed. Potential hypoglycemic reactions in diabetic patients. Reports of lactic acidosis; convulsions; thrombocytopenia. May promote overgrowth of non-susceptible organisms. Has not been studied in patients w/ uncontrolled HTN, pheochromocytoma, carcinoid syndrome, untreated hyperthyroidism. Safety & efficacy of treatment >28 days have not been evaluated. Prompt ophth evaluation is recommended if patients experience symptoms of visual impairment eg, changes in visual acuity & colour vision, blurred vision, or visual field defect. Caution in patients w/ severe renal insufficiency; <40 kg. Should be used during pregnancy only if potential benefit justifies potential risk to the fetus. Discontinue treatment prior to or during breast-feeding.

Headache, fever, sepsis; diarrhea, nausea; rash; anemia.

Potential interaction w/ adrenergic & serotonergic agents. Potential reversible enhancement of pressor response to indirect-acting sympathomimetic agents, vasopressor or dopaminergic agents eg, phenylpropanolamine & pseudoephedrine. Significant pressor response w/ tyramine (>100 mg). Spontaneous reports of serotonin syndrome w/ serotonergic agents, including antidepressants eg, SSRIs.

Other Antibiotics

J01XX08 - linezolid ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.

Rx