Lamido Dosage/Direction for Use

Epilepsy: Adult (>12 years): Monotherapy: Initially 25 mg once daily for 2 weeks, followed by 50 mg once daily for 2 weeks. Doses should be increased by maximum of 50-100 mg every 1-2 weeks until optimal response is obtained. Maintenance dose: 100-200 mg once daily or 2 divided doses up to 500 mg daily. Add-on therapy: Adult (>12 years): Initially 25 mg every alternate day for 2 weeks, followed by 25 mg once daily for 2 weeks, then increase dose by maximum of 25-50 mg every 1-2 weeks. Maintenance dose: 100-200 mg daily once daily or in 2 divided doses.
Patients taking concomitant AEDs or other medications that induce lamotrigine glucuronidation with or without AEDs (except valproate): Initially 50 mg once daily for 2 weeks, followed by 100 mg daily in 2 divided doses for 2 weeks. Then, increase dose by maximum of 100 mg every 1-2 weeks. Maintenance dose: 200-400 mg daily in 2 divided doses up to 700 mg daily.
Patients taking other medications that do not significantly inhibit or induce lamotrigine glucuronidation: Initially 25 mg once daily for 2 weeks, followed by 50 mg once daily for 2 weeks. Then, increase dose by maximum of 50-100 mg every 1-2 weeks. Maintenance dose: 100-200 mg once daily or in 2 divided doses.
Children 2-12 years: Add-on therapy: Patient taking valproate with or without any other AEDs: Initially 0.15 mg/kg/day once daily for 2 weeks, followed by 0.3 mg/kg/day once daily for 2 weeks. Then, increase dose by maximum of 0.3 mg/kg every 1-2 weeks. Maintenance dose: 1-5 mg/kg/day once daily or in 2 divided dose. Maximum dose: 200 mg daily.
Patient taking concomitant AEDs or other medications that induce lamotrigine glucuronidase with or without other AEDs (except valproate): Initially 0.6 mg/kg/day in 2 divided doses for 2 weeks, followed by 1.2 mg/kg/day in 2 divided doses for 2 weeks. Then, increase dose by maximum of 1.2 mg/kg every 1-2 weeks. Maintenance dose: 5-15 mg/kg/day in 2 divided doses. Maximum dose: 400 mg daily.
Patient taking other medications that do not significantly inhibit or induce lamotrigine glucuronidation: Initially 0.3 mg/kg/day once daily or in 2 divided doses for 2 weeks, followed by 0.6 mg/kg/day once daily or in 2 divided doses for 2 weeks. Then, increase dose by maximum of 0.6 mg/kg every 1-2 weeks. Maintenance dose: 1-10 mg/kg/day once daily or in 2 divided doses. Maximum dose: 200 mg daily.
Bipolar disorder: Adult (≥18 years): Adjunct therapy with lamotrigine glucuronidation inhibitors eg, valproate: Initially 25 mg every alternate day for 2 weeks, followed by 25 mg once daily for 2 weeks. Then, increase dose to 50 mg once daily or in 2 divided doses in week 5. Usual target dose: 100 mg once daily or in 2 divided doses. Maximum dose: 200 mg daily.
Adjunct therapy with lamotrigine glucuronidase inducers in patients not taking inhibitors eg, valproate (should be used with phenytoin, carbamazepine, phenobarbitone, primidone, or other drugs known to induce lamotrigine glucuronidation): Initially 50 mg once daily for 2 weeks, followed by 100 mg in 2 divided doses for 2 weeks. Then, increase dose to 200 mg/day in 2 divided doses in week 5. May be increased further to 300 mg/day in week 6. Usual target dose: 400 mg/day in 2 divided dose for week 7.
Monotherapy of adjunct therapy in patient taking other medications that do not significantly induce or inhibit lamotrigine glucuronidation: Initially 25 mg once daily for 2 weeks, followed by 50 mg once daily or in 2 divided dose for 2 weeks. Increase dose to: 100 mg once daily or in 2 divided doses for 2 weeks. Then, increase dose to 100 mg/day in week 5. Usual target dose: 200 mg/day once daily or in 2 divided doses.
Following withdrawal lamotrigine glucuronidation inhibitors, eg, valproate, increase dose to double the original target stabilization dose and maintain. Following withdrawal of adjunct therapy with lamotrigine glucuronidation inducers depending on original maintenance dose. This regimen should be used with phenytoin, carbamazepine, phenobarbitone, primidone, or other drugs known to induce lamotrigine glucuronidation. Gradually reduce dose over 3 weeks. Following withdrawal adjunct therapy with other drugs that do not significantly inhibit or induce lamotrigine glucuronidation, maintain target dose.
Administration: To be taken with or without meals. Swallow whole, do not chew/crush.