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Reduce the dose in patients who have renal insufficiency due to risk of accumulation.
In massive hematuria from the upper urinary tract (especially in haemophilia) since, in a few cases, ureteric obstruction has been reported.
In the long-term treatment of patients with hereditary angioneurotic oedema regular eye examination (e.g. visual acuity, slit lamp, intraocular pressure, visual fields) and liver function tests should be performed.
Use in Pregnancy & Lactation: See USE IN PREGNANCY & LACTATION for further information.
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